Periplaneta americana extract (L.) promotes hair regrowth in Alopecia areata mice by reducing inflammation and modulating skin microbiota

Periplaneta americana extract (L.) promotes hair regrowth in Alopecia areata mice by reducing inflammation and modulating skin microbiota

IntroductionAlopecia areata (AA), an autoimmune hair-loss disease due to follicular inflammatory cell infiltration, lacks an ideal cure. The Periplaneta Americana (PA) extract (PA-011), a traditional Chinese medicine with anti-inflammatory, antioxidant, tissue-repair-promoting, and immune-regulating...

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Main Authors: Tangfei Guan, Xin Yang, Canhui Hong, Jiali Zhu, Peiyun Xiao, Yongshou Yang, Chenggui Zhang, Zhengchun He
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Pharmacology
Subjects:
Alopecia areata
Periplaneta americana (L.) extract
network pharmacology
transcriptomics
metabolomics
microbiomics
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1590648/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1590648/full

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