Impairment of Muscle Function Causes Pupal Lethality in Flies Expressing the Mitochondrial Alternative Oxidase

Impairment of Muscle Function Causes Pupal Lethality in Flies Expressing the Mitochondrial Alternative Oxidase

The mitochondrial alternative oxidase (AOX) from the tunicate <i>Ciona intestinalis</i> has been explored as a potential therapeutic enzyme for human mitochondrial diseases, yet its systemic effects remain poorly understood. Here, we investigate the metabolic and physiological consequenc...

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Bibliographic Details
Main Authors: Carlos A. Couto-Lima, Sina Saari, Geovana S. Garcia, Gabriel H. Rocha, Johanna ten Hoeve, Eric Dufour, Marcos T. Oliveira
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Biomolecules
Subjects:
mitochondria
amino acid metabolism
nutrient deprivation
oxidative phosphorylation
musculature
Online Access:https://www.mdpi.com/2218-273X/15/4/570
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