Gut microbiota composition is associated with the efficacy of Delta-24-RGDOX in malignant gliomas

Gut microbiota composition is associated with the efficacy of Delta-24-RGDOX in malignant gliomas

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Glioblastoma, the most common primary brain tumor, has a 6.8% survival rate 5 years post diagnosis. Our team developed an oncolytic adenovirus with an OX-40L expression cassette named Delta-24-RGDOX. While studies have revealed the interaction between the gut microbiota and immunotherapy agents, no...

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Bibliographic Details
Main Authors: Natalie M. Meléndez-Vázquez, Teresa T. Nguyen, Xuejun Fan, Andrés R. López-Rivas, Juan Fueyo, Candelaria Gomez-Manzano, Filipa Godoy-Vitorino
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Molecular Therapy: Oncology
Subjects:
MT: Regular Issue
gut microbiota
viroimmunotherapy
glioblastoma
oncolytic virus
Delta-24-RGDOX
Online Access:http://www.sciencedirect.com/science/article/pii/S2950329924000298
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