A functional polymorphism in the promoter region of microRNA-146a is associated with the risk of Alzheimer disease and the rate of cognitive decline in patients.

A functional polymorphism in the promoter region of microRNA-146a is associated with the risk of Alzheimer disease and the rate of cognitive decline in patients.

miR146a is well known for its regulatory role in the immune response and inflammation. Recent studies have demonstrated the links between miR146a and Alzheimer disease (AD) and suggested that miR146a may be involved in neuroinflammation and the metabolism of amyloid-β (Aβ), which are critical events...

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Bibliographic Details
Main Authors: Lili Cui, You Li, Guoda Ma, Yan Wang, Yujie Cai, Shengyuan Liu, Yanyan Chen, Jia Li, Yuliu Xie, Gen Liu, Bin Zhao, Keshen Li
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0089019&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0089019&type=printable

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