C/EBPβ activation in vascular smooth muscle cells promotes hyperlipidemia-induced phenotypic transition and arterial stiffness

C/EBPβ activation in vascular smooth muscle cells promotes hyperlipidemia-induced phenotypic transition and arterial stiffness

Abstract Arterial stiffness is a critical factor in cardiovascular and cerebrovascular events, yet clinical practice lacks specific therapeutic targets and biomarkers for its assessment. Hyperlipidemia closely correlates with arterial stiffness, and we observed elevated CCAAT/enhancer-binding protei...

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Main Authors: Jun Ma, Xiangyu Yang, Yanan Li, Xin Zhang, Kai Liu, Yong Peng, Si Wang, Rufeng Shi, Xingwei Huo, Xueting Liu, Xinran Li, Runyu Ye, Zhipeng Zhang, Changqiang Yang, Lu Liu, Dan Gao, Shanshan Jia, Lirong Sun, Xianghao Zuo, Qingtao Meng, Xiaoping Chen
Format: Article
Language:English
Published: Nature Publishing Group 2025-04-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-025-02196-w
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https://doi.org/10.1038/s41392-025-02196-w

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