NRF2 maintains redox balance via ME1 and NRF2 inhibitor synergizes with venetoclax in NPM1-mutated acute myeloid leukemia

NRF2 maintains redox balance via ME1 and NRF2 inhibitor synergizes with venetoclax in NPM1-mutated acute myeloid leukemia

Abstract Background Acute myeloid leukemia (AML) with nucleophosmin 1 (NPM1) mutations represents a distinct subtype of leukemia. Emerging evidence suggests that regulation of redox metabolism contributes to tumorigenesis and reveals a metabolic vulnerability in anti-tumor therapies. However, the ro...

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Main Authors: Jiayuan Hu, Zihao Yuan, Yan Shu, Jun Ren, Jing Yang, Lisha Tang, Xingyu Wei, Yongcan Liu, Fangfang Jin, Qiaoling Xiao, Xinyi Chen, Nan Wu, Wen Zhao, Ziwei Li, Ling Zhang
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Cancer & Metabolism
Subjects:
Acute myeloid leukemia
Nucleophosmin 1
NRF2
ME1
Redox homeostasis
Venetoclax
Online Access:https://doi.org/10.1186/s40170-025-00401-6
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https://doi.org/10.1186/s40170-025-00401-6

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