Epigallocatechin-3-gallate binds tandem RNA recognition motifs of TDP-43 and inhibits its aggregation

Epigallocatechin-3-gallate binds tandem RNA recognition motifs of TDP-43 and inhibits its aggregation

Abstract Transactive response DNA-binding Protein 43 (TDP-43) aggregation is a key pathological feature in Amyotrophic Lateral Sclerosis and related neurodegenerative diseases. This study investigates the inhibitory effects of Epigallocatechin-3-gallate (EGCG), a polyphenol found in green tea, on TD...

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Main Authors: Maria Agnese Morando, Vito D’Alessandro, Angelo Spinello, Martina Sollazzo, Elisa Monaca, Raffaele Sabbatella, Maria Concetta Volpe, Francesca Gervaso, Alessandro Polini, Sarah Mizielinska, Caterina Alfano
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
EGCG stability
TDP-43
ALS
Protein aggregation
RNA-binding proteins
Protein-ligand interaction
Online Access:https://doi.org/10.1038/s41598-025-02035-6
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https://doi.org/10.1038/s41598-025-02035-6

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