Polymorphisms in CYP3A5, CYP3A4, and ABCB1 genes: implications for calcineurin inhibitors therapy in hematopoietic cell transplantation recipients—a systematic review

Polymorphisms in CYP3A5, CYP3A4, and ABCB1 genes: implications for calcineurin inhibitors therapy in hematopoietic cell transplantation recipients—a systematic review

This systematic review assessed the impact of CYP3A5, CYP3A4, and ABCB1 polymorphisms on the pharmacokinetics and clinical outcomes of calcineurin inhibitors in hematopoietic cell transplantation (HCT) recipients. Following PRISMA 2020 guidelines, the protocol was registered in PROSPERO (CRD42024517...

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Main Authors: Luiz Carlos da Costa-Junior, Daniely Regina Freitas-Alves, Amanda Melo Leite Leão, Hayra de Andrade Vieira Monteiro, Rita de Cássia Barbosa da Silva Tavares, Maria Claudia Rodrigues Moreira, Marília Berlofa Visacri, Teresa de Souza Fernandez, Paulo Caleb Júnior de Lima Santos
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Pharmacology
Subjects:
CYP3A5
CYP3A4
ABCB1
calcineurin inhibitors
hematopoietic cell transplantation
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1569353/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1569353/full

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