An integrative approach to prioritize candidate causal genes for complex traits in cattle.

An integrative approach to prioritize candidate causal genes for complex traits in cattle.

Genome-wide association studies (GWAS) have identified many quantitative trait loci (QTL) associated with complex traits, predominantly in non-coding regions, posing challenges in pinpointing the causal variants and their target genes. Three types of evidence can help identify the gene through which...

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Main Authors: Mohammad Ghoreishifar, Iona M Macleod, Amanda J Chamberlain, Zhiqian Liu, Thomas J Lopdell, Mathew D Littlejohn, Ruidong Xiang, Jennie E Pryce, Michael E Goddard
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-05-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1011492
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https://doi.org/10.1371/journal.pgen.1011492

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