Air pollution-induced proteomic alterations increase the risk of child respiratory infections
Abstract Early life air pollution exposure may play a role in development of respiratory infections, but underlying mechanisms are still not understood. We utilized data from two independent prospective birth cohorts to investigate the influence of prenatal and postnatal ambient air pollution exposu...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-07-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-025-61392-y |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849402203039596544 |
|---|---|
| author | Nicklas Brustad Tingting Wang Shizhen He Casper-Emil Tingskov Pedersen Olena Gruzieva Liang Chen Göran Pershagen Mina Ali Julie Nyholm Kyvsgaard Marie Pedersen Matthias Ketzel Heikki Hyöty Daniel Agardh Erik Melén Jonathan Thorsen Jakob Stokholm Klaus Bønnelykke Bo Chawes |
| author_facet | Nicklas Brustad Tingting Wang Shizhen He Casper-Emil Tingskov Pedersen Olena Gruzieva Liang Chen Göran Pershagen Mina Ali Julie Nyholm Kyvsgaard Marie Pedersen Matthias Ketzel Heikki Hyöty Daniel Agardh Erik Melén Jonathan Thorsen Jakob Stokholm Klaus Bønnelykke Bo Chawes |
| author_sort | Nicklas Brustad |
| collection | DOAJ |
| description | Abstract Early life air pollution exposure may play a role in development of respiratory infections, but underlying mechanisms are still not understood. We utilized data from two independent prospective birth cohorts to investigate the influence of prenatal and postnatal ambient air pollution exposure of PM2.5, PM10 and NO2 on maternal and child proteomic profiles and the risk of daily diary-registered common infections age 0-3 years in the Danish COPSAC2010 (n = 613) and pneumonia, croup and bronchitis age 1-2 years in the Swedish EMIL (n = 101). A supervised sparse partial least square model generated proteomic fingerprints of air pollution analyzed against infection outcomes using Quasi-Poisson and logistic regression models, respectively. Here we demonstrated that prenatal ambient air pollution exposure was associated with altered maternal proteomic profile with significant downregulation of the AXIN1 protein. The prenatal air pollution proteomic fingerprints related to a significantly higher risk of total number of infections, cold, pneumonia and fever episodes in COPSAC2010 and similar postnatal air pollution proteomic fingerprints related to a significantly higher risk of respiratory infections in EMIL. Higher AXIN1 protein levels associated with significantly decreased risks of total number of infections, cold, pneumonia, tonsillitis and fever episodes, and asthma risk in COPSAC2010 and a significantly decreased risk of respiratory infections in EMIL suggesting a protective effect of this specific protein in both cohorts. This study of two prospective birth cohorts demonstrates ambient air pollution alterations in the maternal and child’s proteomic profiles that associates with respiratory infection risk suggesting the AXIN1 protein as a potential target for respiratory infection and asthma prevention in childhood. |
| format | Article |
| id | doaj-art-059f54f51e55458caf697254642eb0a7 |
| institution | Kabale University |
| issn | 2041-1723 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-059f54f51e55458caf697254642eb0a72025-08-20T03:37:37ZengNature PortfolioNature Communications2041-17232025-07-0116111010.1038/s41467-025-61392-yAir pollution-induced proteomic alterations increase the risk of child respiratory infectionsNicklas Brustad0Tingting Wang1Shizhen He2Casper-Emil Tingskov Pedersen3Olena Gruzieva4Liang Chen5Göran Pershagen6Mina Ali7Julie Nyholm Kyvsgaard8Marie Pedersen9Matthias Ketzel10Heikki Hyöty11Daniel Agardh12Erik Melén13Jonathan Thorsen14Jakob Stokholm15Klaus Bønnelykke16Bo Chawes17COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Copenhagen University Hospital - Herlev and GentofteCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Copenhagen University Hospital - Herlev and GentofteInstitute of Environmental Medicine, Karolinska InstitutetCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Copenhagen University Hospital - Herlev and GentofteInstitute of Environmental Medicine, Karolinska InstitutetCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Copenhagen University Hospital - Herlev and GentofteInstitute of Environmental Medicine, Karolinska InstitutetCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Copenhagen University Hospital - Herlev and GentofteCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Copenhagen University Hospital - Herlev and GentofteDepartment of Public Health, University of CopenhagenDepartment of Environmental Science, Aarhus UniversityFaculty of Medicine and Health Technology, Tampere University, and Fimlab LaboratoriesDepartment of Clinical Sciences, Lund UniversityDepartment of Clinical Science and Education, Södersjukhuset, Karolinska InstitutetCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Copenhagen University Hospital - Herlev and GentofteCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Copenhagen University Hospital - Herlev and GentofteCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Copenhagen University Hospital - Herlev and GentofteCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Copenhagen University Hospital - Herlev and GentofteAbstract Early life air pollution exposure may play a role in development of respiratory infections, but underlying mechanisms are still not understood. We utilized data from two independent prospective birth cohorts to investigate the influence of prenatal and postnatal ambient air pollution exposure of PM2.5, PM10 and NO2 on maternal and child proteomic profiles and the risk of daily diary-registered common infections age 0-3 years in the Danish COPSAC2010 (n = 613) and pneumonia, croup and bronchitis age 1-2 years in the Swedish EMIL (n = 101). A supervised sparse partial least square model generated proteomic fingerprints of air pollution analyzed against infection outcomes using Quasi-Poisson and logistic regression models, respectively. Here we demonstrated that prenatal ambient air pollution exposure was associated with altered maternal proteomic profile with significant downregulation of the AXIN1 protein. The prenatal air pollution proteomic fingerprints related to a significantly higher risk of total number of infections, cold, pneumonia and fever episodes in COPSAC2010 and similar postnatal air pollution proteomic fingerprints related to a significantly higher risk of respiratory infections in EMIL. Higher AXIN1 protein levels associated with significantly decreased risks of total number of infections, cold, pneumonia, tonsillitis and fever episodes, and asthma risk in COPSAC2010 and a significantly decreased risk of respiratory infections in EMIL suggesting a protective effect of this specific protein in both cohorts. This study of two prospective birth cohorts demonstrates ambient air pollution alterations in the maternal and child’s proteomic profiles that associates with respiratory infection risk suggesting the AXIN1 protein as a potential target for respiratory infection and asthma prevention in childhood.https://doi.org/10.1038/s41467-025-61392-y |
| spellingShingle | Nicklas Brustad Tingting Wang Shizhen He Casper-Emil Tingskov Pedersen Olena Gruzieva Liang Chen Göran Pershagen Mina Ali Julie Nyholm Kyvsgaard Marie Pedersen Matthias Ketzel Heikki Hyöty Daniel Agardh Erik Melén Jonathan Thorsen Jakob Stokholm Klaus Bønnelykke Bo Chawes Air pollution-induced proteomic alterations increase the risk of child respiratory infections Nature Communications |
| title | Air pollution-induced proteomic alterations increase the risk of child respiratory infections |
| title_full | Air pollution-induced proteomic alterations increase the risk of child respiratory infections |
| title_fullStr | Air pollution-induced proteomic alterations increase the risk of child respiratory infections |
| title_full_unstemmed | Air pollution-induced proteomic alterations increase the risk of child respiratory infections |
| title_short | Air pollution-induced proteomic alterations increase the risk of child respiratory infections |
| title_sort | air pollution induced proteomic alterations increase the risk of child respiratory infections |
| url | https://doi.org/10.1038/s41467-025-61392-y |
| work_keys_str_mv | AT nicklasbrustad airpollutioninducedproteomicalterationsincreasetheriskofchildrespiratoryinfections AT tingtingwang airpollutioninducedproteomicalterationsincreasetheriskofchildrespiratoryinfections AT shizhenhe airpollutioninducedproteomicalterationsincreasetheriskofchildrespiratoryinfections AT casperemiltingskovpedersen airpollutioninducedproteomicalterationsincreasetheriskofchildrespiratoryinfections AT olenagruzieva airpollutioninducedproteomicalterationsincreasetheriskofchildrespiratoryinfections AT liangchen airpollutioninducedproteomicalterationsincreasetheriskofchildrespiratoryinfections AT goranpershagen airpollutioninducedproteomicalterationsincreasetheriskofchildrespiratoryinfections AT minaali airpollutioninducedproteomicalterationsincreasetheriskofchildrespiratoryinfections AT julienyholmkyvsgaard airpollutioninducedproteomicalterationsincreasetheriskofchildrespiratoryinfections AT mariepedersen airpollutioninducedproteomicalterationsincreasetheriskofchildrespiratoryinfections AT matthiasketzel airpollutioninducedproteomicalterationsincreasetheriskofchildrespiratoryinfections AT heikkihyoty airpollutioninducedproteomicalterationsincreasetheriskofchildrespiratoryinfections AT danielagardh airpollutioninducedproteomicalterationsincreasetheriskofchildrespiratoryinfections AT erikmelen airpollutioninducedproteomicalterationsincreasetheriskofchildrespiratoryinfections AT jonathanthorsen airpollutioninducedproteomicalterationsincreasetheriskofchildrespiratoryinfections AT jakobstokholm airpollutioninducedproteomicalterationsincreasetheriskofchildrespiratoryinfections AT klausbønnelykke airpollutioninducedproteomicalterationsincreasetheriskofchildrespiratoryinfections AT bochawes airpollutioninducedproteomicalterationsincreasetheriskofchildrespiratoryinfections |