National antibiotic consumption is strongly related to the prevalence of antibiotic resistance across bacterial clades
Summary: The impact of societal antibiotic consumption on the prevalence of antibiotic resistance across microbial taxa in natural environments has not yet been assessed at global scales. Here, I examine the prevalence of 155 antibiotic resistance genes (ARGs) in 300,209 bacterial genomes, from non-...
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Elsevier
2025-02-01
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004224029390 |
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| author | Stilianos Louca |
| author_facet | Stilianos Louca |
| author_sort | Stilianos Louca |
| collection | DOAJ |
| description | Summary: The impact of societal antibiotic consumption on the prevalence of antibiotic resistance across microbial taxa in natural environments has not yet been assessed at global scales. Here, I examine the prevalence of 155 antibiotic resistance genes (ARGs) in 300,209 bacterial genomes, from non-clinical non-human-associated terrestrial environments at over 9,600 locations in 44 countries. I then compare ARG prevalences to nationwide antibiotic consumption rates, distinguishing between different ARG types. I find that depending on country and ARG type, ARG prevalences can be extremely high; for example, the probability that a given quinolone resistance gene is present in a given strain in Thailand was estimated at 42%. Further, I find strong positive correlations between nationwide antibiotic consumption rates and mean ARG prevalences for nearly all ARG types. Thus, national antibiotic consumption leaves a signal on the prevalence of ARGs across the bacterial tree, even in non-clinical environments. |
| format | Article |
| id | doaj-art-059c374b8a3e46e8b86a59bab549cea0 |
| institution | Kabale University |
| issn | 2589-0042 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj-art-059c374b8a3e46e8b86a59bab549cea02025-01-18T05:05:04ZengElsevieriScience2589-00422025-02-01282111712National antibiotic consumption is strongly related to the prevalence of antibiotic resistance across bacterial cladesStilianos Louca0Department of Biology, University of Oregon, Eugene, OR 97403, USA; Institute of Ecology and Evolution, University of Oregon, Eugene, OR 97403, USA; Corresponding authorSummary: The impact of societal antibiotic consumption on the prevalence of antibiotic resistance across microbial taxa in natural environments has not yet been assessed at global scales. Here, I examine the prevalence of 155 antibiotic resistance genes (ARGs) in 300,209 bacterial genomes, from non-clinical non-human-associated terrestrial environments at over 9,600 locations in 44 countries. I then compare ARG prevalences to nationwide antibiotic consumption rates, distinguishing between different ARG types. I find that depending on country and ARG type, ARG prevalences can be extremely high; for example, the probability that a given quinolone resistance gene is present in a given strain in Thailand was estimated at 42%. Further, I find strong positive correlations between nationwide antibiotic consumption rates and mean ARG prevalences for nearly all ARG types. Thus, national antibiotic consumption leaves a signal on the prevalence of ARGs across the bacterial tree, even in non-clinical environments.http://www.sciencedirect.com/science/article/pii/S2589004224029390natural sciencesbiological sciencesmicrobiologyclinical microbiology |
| spellingShingle | Stilianos Louca National antibiotic consumption is strongly related to the prevalence of antibiotic resistance across bacterial clades iScience natural sciences biological sciences microbiology clinical microbiology |
| title | National antibiotic consumption is strongly related to the prevalence of antibiotic resistance across bacterial clades |
| title_full | National antibiotic consumption is strongly related to the prevalence of antibiotic resistance across bacterial clades |
| title_fullStr | National antibiotic consumption is strongly related to the prevalence of antibiotic resistance across bacterial clades |
| title_full_unstemmed | National antibiotic consumption is strongly related to the prevalence of antibiotic resistance across bacterial clades |
| title_short | National antibiotic consumption is strongly related to the prevalence of antibiotic resistance across bacterial clades |
| title_sort | national antibiotic consumption is strongly related to the prevalence of antibiotic resistance across bacterial clades |
| topic | natural sciences biological sciences microbiology clinical microbiology |
| url | http://www.sciencedirect.com/science/article/pii/S2589004224029390 |
| work_keys_str_mv | AT stilianoslouca nationalantibioticconsumptionisstronglyrelatedtotheprevalenceofantibioticresistanceacrossbacterialclades |