Synthesis and Antimicrobial Activity of Some Novel Substituted Piperazinyl-quinazolin-3(4H)-ones
Several substituted-quinazolin-3(4H)-ones were synthesized by condensation of 2-chloro-N-(4-oxo-substituted-quinazolin-3(4H)-yl)-acetamides with various substituted piperazines through single step reaction. Elemental analysis, IR, 1HNMR and mass spectral data confirmed the structure of the newly syn...
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| Format: | Article |
| Language: | English |
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Wiley
2008-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2008/410157 |
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| author | N. M. Raghavendra P. P. Thampi P. M. Gurubasavarajaswamy |
| author_facet | N. M. Raghavendra P. P. Thampi P. M. Gurubasavarajaswamy |
| author_sort | N. M. Raghavendra |
| collection | DOAJ |
| description | Several substituted-quinazolin-3(4H)-ones were synthesized by condensation of 2-chloro-N-(4-oxo-substituted-quinazolin-3(4H)-yl)-acetamides with various substituted piperazines through single step reaction. Elemental analysis, IR, 1HNMR and mass spectral data confirmed the structure of the newly synthesized compounds. Synthesized quinazolin-4-one derivatives were investigated for their antibacterial and antifungal activities. |
| format | Article |
| id | doaj-art-059b91f420544f009505324fac789b75 |
| institution | OA Journals |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2008-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-059b91f420544f009505324fac789b752025-08-20T02:02:58ZengWileyE-Journal of Chemistry0973-49452090-98102008-01-0151233310.1155/2008/410157Synthesis and Antimicrobial Activity of Some Novel Substituted Piperazinyl-quinazolin-3(4H)-onesN. M. Raghavendra0P. P. Thampi1P. M. Gurubasavarajaswamy2Medicinal Chemistry Research Laboratory, Acharya and B.M. Reddy College of Pharmacy, Bangalore, Karnataka, IndiaMedicinal Chemistry Research Laboratory, Acharya and B.M. Reddy College of Pharmacy, Bangalore, Karnataka, IndiaMedicinal Chemistry Research Laboratory, Acharya and B.M. Reddy College of Pharmacy, Bangalore, Karnataka, IndiaSeveral substituted-quinazolin-3(4H)-ones were synthesized by condensation of 2-chloro-N-(4-oxo-substituted-quinazolin-3(4H)-yl)-acetamides with various substituted piperazines through single step reaction. Elemental analysis, IR, 1HNMR and mass spectral data confirmed the structure of the newly synthesized compounds. Synthesized quinazolin-4-one derivatives were investigated for their antibacterial and antifungal activities.http://dx.doi.org/10.1155/2008/410157 |
| spellingShingle | N. M. Raghavendra P. P. Thampi P. M. Gurubasavarajaswamy Synthesis and Antimicrobial Activity of Some Novel Substituted Piperazinyl-quinazolin-3(4H)-ones E-Journal of Chemistry |
| title | Synthesis and Antimicrobial Activity of Some Novel Substituted Piperazinyl-quinazolin-3(4H)-ones |
| title_full | Synthesis and Antimicrobial Activity of Some Novel Substituted Piperazinyl-quinazolin-3(4H)-ones |
| title_fullStr | Synthesis and Antimicrobial Activity of Some Novel Substituted Piperazinyl-quinazolin-3(4H)-ones |
| title_full_unstemmed | Synthesis and Antimicrobial Activity of Some Novel Substituted Piperazinyl-quinazolin-3(4H)-ones |
| title_short | Synthesis and Antimicrobial Activity of Some Novel Substituted Piperazinyl-quinazolin-3(4H)-ones |
| title_sort | synthesis and antimicrobial activity of some novel substituted piperazinyl quinazolin 3 4h ones |
| url | http://dx.doi.org/10.1155/2008/410157 |
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