miR‐17/20 Controls Prolyl Hydroxylase 2 (PHD2)/Hypoxia‐Inducible Factor 1 (HIF1) to Regulate Pulmonary Artery Smooth Muscle Cell Proliferation
Background Previously we found that smooth muscle cell (SMC)‐specific knockout of miR‐17~92 attenuates hypoxia‐induced pulmonary hypertension. However, the mechanism underlying miR‐17~92‐mediated pulmonary artery SMC (PASMC) proliferation remains unclear. We sought to investigate whether miR‐17~92 r...
Saved in:
| Main Authors: | Tianji Chen, Qiyuan Zhou, Haiyang Tang, Melike Bozkanat, Jason X.‐J. Yuan, J. Usha Raj, Guofei Zhou |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-12-01
|
| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.116.004510 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Issues on clinical application of hypoxia-inducible factor prolyl hydroxylase inhibitor Roxadustat
by: TU Yan, et al.
Published: (2020-01-01) -
Prolyl Hydroxylase Inhibitor-Mediated HIF Activation Drives Transcriptional Reprogramming in Retinal Pigment Epithelium: Relevance to Chronic Kidney Disease
by: Tamás Gáll, et al.
Published: (2025-07-01) -
Association of <i>Helicobacter pylori</i> with Serum HIF-1α, HIF-2α, and Human Transmembrane Prolyl 4-Hydroxylase Activity in Patients with Chronic Gastritis
by: Sefa Ergün, et al.
Published: (2025-06-01) -
Progress of HIF-1α and HIF-PHI in vascular calcification of chronic kidney disease
by: WANG Ao, et al.
Published: (2024-08-01) -
Effects of hypoxia-inducible factor prolyl hydroxylase inhibitors on hemoglobin, B-type natriuretic peptide, and renal function in anemic heart failure patients: A systematic review and meta-analysis
by: Hidekatsu Fukuta, et al.
Published: (2025-06-01)