Immune profiling of the macroenvironment in colorectal cancer unveils systemic dysfunction and plasticity of immune cells

Immune profiling of the macroenvironment in colorectal cancer unveils systemic dysfunction and plasticity of immune cells

Abstract Background Tumour immune macroenvironment is comprised of tumour and surrounding organs responding to tumourigenesis and immunotherapy. The lack of comprehensive analytical methods hinders its application for prediction of survival and treatment response in colorectal cancer (CRC) patients....

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Main Authors: Haoxian Ke, Peisi Li, Zhihao Li, Xian Zeng, Chi Zhang, Shuzhen Luo, Xiaofang Chen, Xinlan Zhou, Shichen Dong, Shaopeng Chen, Junfeng Huang, Ming Yuan, Runfeng Yu, Shubiao Ye, Tuo Hu, Zhonghui Tang, Dongbin Liu, Kui Wu, Xianrui Wu, Ping Lan
Format: Article
Language:English
Published: Wiley 2025-02-01
Series:Clinical and Translational Medicine
Subjects:
colorectal cancer
single‐cell omics
spatial transcription
tumour macroenvironment
Online Access:https://doi.org/10.1002/ctm2.70175
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https://doi.org/10.1002/ctm2.70175

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