Immunotherapy against tau fragment diminishes AD pathology, improving synaptic function and cognition

Immunotherapy against tau fragment diminishes AD pathology, improving synaptic function and cognition

Abstract Background Asparagine endopeptidase (AEP) is implicated in the pathogenesis of Alzheimer’s disease (AD) by cleaving Tau at residue N368, accelerating its hyperphosphorylation and aggregation. The Tau N368/t-Tau ratio in cerebrospinal fluid (CSF) serves as a superior biomarker compared to es...

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Bibliographic Details
Main Authors: Jie Xiang, Zhengjiang Qian, Ye Xi, Yanuo Wei, Guangxing Wang, Xia Liu, Zhi-Hao Wang, Zhentao Zhang, Shengxi Wu, Keqiang Ye
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Molecular Neurodegeneration
Subjects:
TrkB receptors
Neurofibrillary tangles (NFTs)
Tau N368 antibody
AEP
Alzheimer’s disease
Online Access:https://doi.org/10.1186/s13024-025-00854-9
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https://doi.org/10.1186/s13024-025-00854-9

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