Targeting FDFT1 Reduces Cholesterol and Bile Acid Production and Delays Hepatocellular Carcinoma Progression Through the HNF4A/ALDOB/AKT1 Axis

Targeting FDFT1 Reduces Cholesterol and Bile Acid Production and Delays Hepatocellular Carcinoma Progression Through the HNF4A/ALDOB/AKT1 Axis

Abstract Targeting cholesterol metabolism is a novel direction for tumor therapy. Unfortunately, the current use of statins for hepatocellular carcinoma (HCC) is controversial. Herein, farnesyl‐diphosphate farnesyltransferase 1 (FDFT1) is identified as a novel target for treating HCC and a potential...

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Bibliographic Details
Main Authors: Dong Cai, Guo‐Chao Zhong, Xin Dai, Zhibo Zhao, Menglin Chen, Jiejun Hu, Zhenru Wu, Lve Cheng, Shengwei Li, Jianping Gong
Format: Article
Language:English
Published: Wiley 2025-03-01
Series:Advanced Science
Subjects:
bile acid
cholesterol
FDFT1
hepatocellular carcinoma
proliferation
Online Access:https://doi.org/10.1002/advs.202411719
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https://doi.org/10.1002/advs.202411719

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