Tumor-Induced Osteomalacia in a Patient With FGF23-Amplified Lung Adenocarcinoma and FGF23-Deleted SCLC: Case Report
Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome characterized by ectopic fibroblast growth factor-23 (FGF23) production. We report a unique case of a 78-year-old female patient with refractory hypophosphatemia, ultimately diagnosed as TIO, in the context of two metastatic primary...
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Elsevier
2025-06-01
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| Series: | JTO Clinical and Research Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666364325000384 |
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| author | Marcello Moro Queiroz, MD Ricardo Dahmer Tiecher, MD João Felipe Lima Feldmann, MD Elisangela Monteiro Coser, BSc Mariana Vargas Cruz, PhD Livia Loureiro, PhD Gabriela Franco Katz, MD Marina Henkin Behar, MD João Victor Machado Alessi, MD Leonardo de Abreu Testagrossa, PhD Anamaria Aranha Camargo, PhD Paula Fontes Asprino, PhD Fabiana Bettoni, PhD Artur Katz, MD |
| author_facet | Marcello Moro Queiroz, MD Ricardo Dahmer Tiecher, MD João Felipe Lima Feldmann, MD Elisangela Monteiro Coser, BSc Mariana Vargas Cruz, PhD Livia Loureiro, PhD Gabriela Franco Katz, MD Marina Henkin Behar, MD João Victor Machado Alessi, MD Leonardo de Abreu Testagrossa, PhD Anamaria Aranha Camargo, PhD Paula Fontes Asprino, PhD Fabiana Bettoni, PhD Artur Katz, MD |
| author_sort | Marcello Moro Queiroz, MD |
| collection | DOAJ |
| description | Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome characterized by ectopic fibroblast growth factor-23 (FGF23) production. We report a unique case of a 78-year-old female patient with refractory hypophosphatemia, ultimately diagnosed as TIO, in the context of two metastatic primary lung cancers: adenocarcinoma and SCLC. Molecular analyses of tumor samples highlighted FGF23 amplification in one adenocarcinoma sample and FGF23 deletion in one SCLC sample, suggesting a potential link between tumor FGF23 molecular alterations and elevated serum FGF23 levels. This case underscores the complexity of diagnoses and management of TIO when associated with solid tumors and highlights the need for awareness of this condition to prevent diagnostic delays. Future research should explore the mechanisms linking FGF23 alterations and cancer progression and evaluate targeted therapies for TIO in the context of resistant metastatic cancers. |
| format | Article |
| id | doaj-art-050888bd159b4e82a4651264ddf89370 |
| institution | Kabale University |
| issn | 2666-3643 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | JTO Clinical and Research Reports |
| spelling | doaj-art-050888bd159b4e82a4651264ddf893702025-08-20T03:24:52ZengElsevierJTO Clinical and Research Reports2666-36432025-06-016610082210.1016/j.jtocrr.2025.100822Tumor-Induced Osteomalacia in a Patient With FGF23-Amplified Lung Adenocarcinoma and FGF23-Deleted SCLC: Case ReportMarcello Moro Queiroz, MD0Ricardo Dahmer Tiecher, MD1João Felipe Lima Feldmann, MD2Elisangela Monteiro Coser, BSc3Mariana Vargas Cruz, PhD4Livia Loureiro, PhD5Gabriela Franco Katz, MD6Marina Henkin Behar, MD7João Victor Machado Alessi, MD8Leonardo de Abreu Testagrossa, PhD9Anamaria Aranha Camargo, PhD10Paula Fontes Asprino, PhD11Fabiana Bettoni, PhD12Artur Katz, MD13Oncology Center, Hospital Sírio-Libanês, São Paulo, São Paulo, Brazil; Corresponding author. Address for correspondence: Marcello Moro Queiroz, MD, Oncology Center, Hospital Sírio-Libanês, Street Adma Jafet, number 115, São Paulo, São Paulo, 01308-050, Brazil.Oncology Center, Hospital Sírio-Libanês, São Paulo, São Paulo, BrazilOncology Center, Hospital Sírio-Libanês, São Paulo, São Paulo, BrazilMolecular Oncology Center, Hospital Sírio-Libanês, São Paulo, São Paulo, BrazilDepartment of Pathology, Hospital Sírio-Libanês, São Paulo, São Paulo, BrazilMedical Affairs Organization, Illumina, São Paulo, São Paulo, BrazilUniversity of Central Lancashire, Preston, United KingdomOncology Center, Hospital Sírio-Libanês, São Paulo, São Paulo, BrazilOncology Center, Hospital Sírio-Libanês, São Paulo, São Paulo, BrazilDepartment of Pathology, Hospital Sírio-Libanês, São Paulo, São Paulo, BrazilMolecular Oncology Center, Hospital Sírio-Libanês, São Paulo, São Paulo, BrazilMolecular Oncology Center, Hospital Sírio-Libanês, São Paulo, São Paulo, BrazilMolecular Oncology Center, Hospital Sírio-Libanês, São Paulo, São Paulo, BrazilOncology Center, Hospital Sírio-Libanês, São Paulo, São Paulo, BrazilTumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome characterized by ectopic fibroblast growth factor-23 (FGF23) production. We report a unique case of a 78-year-old female patient with refractory hypophosphatemia, ultimately diagnosed as TIO, in the context of two metastatic primary lung cancers: adenocarcinoma and SCLC. Molecular analyses of tumor samples highlighted FGF23 amplification in one adenocarcinoma sample and FGF23 deletion in one SCLC sample, suggesting a potential link between tumor FGF23 molecular alterations and elevated serum FGF23 levels. This case underscores the complexity of diagnoses and management of TIO when associated with solid tumors and highlights the need for awareness of this condition to prevent diagnostic delays. Future research should explore the mechanisms linking FGF23 alterations and cancer progression and evaluate targeted therapies for TIO in the context of resistant metastatic cancers.http://www.sciencedirect.com/science/article/pii/S2666364325000384Tumor-induced osteomalaciaLung adenocarcinomaFibroblast growth factor-23Case report |
| spellingShingle | Marcello Moro Queiroz, MD Ricardo Dahmer Tiecher, MD João Felipe Lima Feldmann, MD Elisangela Monteiro Coser, BSc Mariana Vargas Cruz, PhD Livia Loureiro, PhD Gabriela Franco Katz, MD Marina Henkin Behar, MD João Victor Machado Alessi, MD Leonardo de Abreu Testagrossa, PhD Anamaria Aranha Camargo, PhD Paula Fontes Asprino, PhD Fabiana Bettoni, PhD Artur Katz, MD Tumor-Induced Osteomalacia in a Patient With FGF23-Amplified Lung Adenocarcinoma and FGF23-Deleted SCLC: Case Report JTO Clinical and Research Reports Tumor-induced osteomalacia Lung adenocarcinoma Fibroblast growth factor-23 Case report |
| title | Tumor-Induced Osteomalacia in a Patient With FGF23-Amplified Lung Adenocarcinoma and FGF23-Deleted SCLC: Case Report |
| title_full | Tumor-Induced Osteomalacia in a Patient With FGF23-Amplified Lung Adenocarcinoma and FGF23-Deleted SCLC: Case Report |
| title_fullStr | Tumor-Induced Osteomalacia in a Patient With FGF23-Amplified Lung Adenocarcinoma and FGF23-Deleted SCLC: Case Report |
| title_full_unstemmed | Tumor-Induced Osteomalacia in a Patient With FGF23-Amplified Lung Adenocarcinoma and FGF23-Deleted SCLC: Case Report |
| title_short | Tumor-Induced Osteomalacia in a Patient With FGF23-Amplified Lung Adenocarcinoma and FGF23-Deleted SCLC: Case Report |
| title_sort | tumor induced osteomalacia in a patient with fgf23 amplified lung adenocarcinoma and fgf23 deleted sclc case report |
| topic | Tumor-induced osteomalacia Lung adenocarcinoma Fibroblast growth factor-23 Case report |
| url | http://www.sciencedirect.com/science/article/pii/S2666364325000384 |
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