Enhancing the reverse transcriptase function in Taq polymerase via AI-driven multiparametric rational design

Enhancing the reverse transcriptase function in Taq polymerase via AI-driven multiparametric rational design

IntroductionModification of natural enzymes to introduce new properties and enhance existing ones is a central challenge in bioengineering. This study is focused on the development of Taq polymerase mutants that show enhanced reverse transcriptase (RTase) activity while retaining other desirable pro...

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Main Authors: Yulia E. Tomilova, Nikolay E. Russkikh, Igor M. Yi, Elizaveta V. Shaburova, Viktor N. Tomilov, Galina B. Pyrinova, Svetlana O. Brezhneva, Olga S. Tikhonyuk, Nadezhda S. Gololobova, Dmitriy V. Popichenko, Maxim O. Arkhipov, Leonid O. Bryzgalov, Evgeniy V. Brenner, Anastasia A. Artyukh, Dmitry N. Shtokalo, Denis V. Antonets, Mikhail K. Ivanov
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
bioengineering
function enhancement
reverse transcription
machine learning
protein language model
rational design
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2024.1495267/full
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https://www.frontiersin.org/articles/10.3389/fbioe.2024.1495267/full

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