Knockdown of RGMa reduces vascular calcification by inhibiting the AKT signaling pathway

Knockdown of RGMa reduces vascular calcification by inhibiting the AKT signaling pathway

Abstract Vascular calcification (VC), pathologically characterized by ectopic calcium-phosphate deposition, demonstrates a significant correlation with cardio-cerebrovascular morbidity and adverse clinical outcomes. Despite its clinical relevance, current interventions to prevent and treat VC progre...

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Bibliographic Details
Main Authors: Hongmei Xiao, Guanru Shen, Zijie Wang, Xiaofan Yuan, Yue Ma, Ruiqi Cheng, Xinyue Qin
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
RGMa
Vascular calcification
VSMCs
VitD3
AKT signaling pathway
Online Access:https://doi.org/10.1038/s41598-025-08481-6
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https://doi.org/10.1038/s41598-025-08481-6

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