High PER1 expression is associated with STK11 mutation and clinical biomarkers of immunotherapy resistance in lung adenocarcinoma
Abstract Aim This study characterizes the functional effects and clinical characteristics of high PER1 mRNA and high PER1 protein expression in treatment resistant lung adenocarcinoma. Methods HBEC3-KT cells were modified by STK11 CRISPR knockout and A549 cells by LKB1 addback using stable transfect...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Springer
2025-07-01
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| Series: | Journal of Cancer Research and Clinical Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/s00432-025-06269-9 |
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