Caloric restriction mimetic 2-deoxyglucose alters metabolic and transcriptomic phenotype in association with changes in chromatin accessibility in human astrocytes

Caloric restriction mimetic 2-deoxyglucose alters metabolic and transcriptomic phenotype in association with changes in chromatin accessibility in human astrocytes

Abstract Caloric restriction and ketogenic diets may modify the progression of neurological disorders, including HIV-associated neurological disorders and Alzheimer’s disease, in part by influencing astrocyte function. This study examines how metabolic substrate availability affects metabolic proces...

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Bibliographic Details
Main Authors: Matthew Spencer, Jacqueline R. Kulbe, Vikram Venkatesh, Anna Laird, Mary Ford, Sydney O’Brien, Ali Boustani, Johannes C. M. Schlachetzki, Jerel Adam Fields
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Scientific Reports
Subjects:
Astrocytes
Immunometabolism
Chromatin accessibility
Glycolysis
Caloric restriction
Neuroinflammation
Online Access:https://doi.org/10.1038/s41598-025-03796-w
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https://doi.org/10.1038/s41598-025-03796-w

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