Cerebral Hemodynamic Impairment and Cognitive Dysfunction in APOE4 Carriers With Asymptomatic Carotid Artery Stenosis/Occlusion

Background Our previous preclinical study demonstrated that APOE4‐targeted replacement mice exhibit more severe cerebral hypoperfusion and cognitive impairment than APOE3‐targeted replacement mice with carotid artery stenosis due to neurovascular dysfunction. Therefore, we clinically investigate whe...

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Bibliographic Details
Main Authors: Yoshinori Kakino, Yorito Hattori, Soshiro Ogata, Yuriko Nakaoku, Kunihiro Nishimura, Hidehiro Iida, Masafumi Ihara
Format: Article
Language:English
Published: Wiley 2025-03-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
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Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.124.039210
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