A novel antidepressant mechanism of baicalin: enhancing KIF5A-mediated axoplasmic transport and vesicular trafficking in glutamatergic neurons

IntroductionDysfunction of axoplasmic transport is closely linked to depression. Baicalin, a major flavonoid in Scutellaria baicalensis, a well-known traditional Chinese medicine used in depression treatment, has demonstrated antidepressant-like effects in previous studies. However, its potential ro...

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Bibliographic Details
Main Authors: Shuaifei Lu, Jiduo Shen, Xiaohui Jin, Changjing Zhang, Baoying Wang, Xianghua Liu, Ming Bai, Erping Xu, Xiangli Yan, Yucheng Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Pharmacology
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Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1577676/full
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