HNRNPC stabilizes m6A-modified AC145207.5 to accelerate tumorigenesis in colorectal cancer by impeding the Nrf2/GPX4 axis-mediated ferroptosis

HNRNPC stabilizes m6A-modified AC145207.5 to accelerate tumorigenesis in colorectal cancer by impeding the Nrf2/GPX4 axis-mediated ferroptosis

Ferroptosis is an apoptosis-independent cell death pathway characterized by heightened lipid peroxidation, which shows promise for tumor suppression. Despite extensive research on long non-coding RNAs (LncRNAs) in ferroptosis, their role in colorectal cancer (CRC) remains underexplored. We investiga...

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Main Authors: Dan Liu, Shanshan Lin, Yueben Hu, Jianyong Xiong, Hongtao Wan, Yanglin Chen, Taohui Ding, Hu Zhao, Renjie Jiang, Zhijiang Huang, Dengke Yao, Ming Li, Xiaojian Zhu, Bo Yi
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2025-08-01
Series:Non-coding RNA Research
Subjects:
m6A
RNA binding protein
Ferroptosis
Nrf2/GPX4 signaling pathway
Online Access:http://www.sciencedirect.com/science/article/pii/S2468054025000411
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