Role of GuaB, the inosine-5′-monophosphate dehydrogenase of uropathogenic Escherichia coli pathogenicity: a key factor for bladder infection

Role of GuaB, the inosine-5′-monophosphate dehydrogenase of uropathogenic Escherichia coli pathogenicity: a key factor for bladder infection

ABSTRACT Uropathogenic Escherichia coli (UPEC) is the primary causative agent of urinary tract infections (UTIs). This bacterium infects the bladder through the urinary tract, and some bacteria ascend to the kidneys, leading to more severe conditions such as pyelonephritis and sepsis. The infection...

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Main Authors: Mizuki Shimokawa, Ayako Takita, Kazutomo Suzue, Ayuko Kimura, Himari Tabo, Yumika Sato, Yuya Yanagita, Takuya Sadahira, Haruyoshi Tomita, Hidetada Hirakawa
Format: Article
Language:English
Published: American Society for Microbiology 2025-08-01
Series:Microbiology Spectrum
Subjects:
urinary tract infection (UTI)
uropathogenic Escherichia coli (UPEC)
bacterial pathogenesis
proteome
antimicrobial resistance (AMR)
virulence
Online Access:https://journals.asm.org/doi/10.1128/spectrum.00221-25
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https://journals.asm.org/doi/10.1128/spectrum.00221-25

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