Advances in the role of the IGF signaling system in myelodysplastic syndromes and acute myeloid leukemia

Advances in the role of the IGF signaling system in myelodysplastic syndromes and acute myeloid leukemia

The insulin-like growth factor (IGF) signaling system comprises functionally specific ligands (IGF-I and IGF-II), receptor (IR), and binding proteins (IGFBP). IGFs are activated by binding to their receptor, IGF-IR, which is a tyrosine kinase receptor. This activation initiates signaling cascades su...

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Bibliographic Details
Main Authors: Yifan Wang, Xinyu Dong, Shandong Tao, Qiuni Chen, Yue Chen, Lijuan Zhang, Yuye Shi, Zhengmei He, Liang Yu, Chunling Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Oncology
Subjects:
IGF-I
IGF-II
IGF receptor
IGF binding proteins
MDS
AML
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1540426/full
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