Advances in the role of the IGF signaling system in myelodysplastic syndromes and acute myeloid leukemia

The insulin-like growth factor (IGF) signaling system comprises functionally specific ligands (IGF-I and IGF-II), receptor (IR), and binding proteins (IGFBP). IGFs are activated by binding to their receptor, IGF-IR, which is a tyrosine kinase receptor. This activation initiates signaling cascades su...

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Bibliographic Details
Main Authors: Yifan Wang, Xinyu Dong, Shandong Tao, Qiuni Chen, Yue Chen, Lijuan Zhang, Yuye Shi, Zhengmei He, Liang Yu, Chunling Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Oncology
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Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1540426/full
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