Exosome-derived miR-548ag drives hepatic lipid accumulation via upregulating FASN through inhibition of DNMT3B

Exosome-derived miR-548ag drives hepatic lipid accumulation via upregulating FASN through inhibition of DNMT3B

Metabolic dysfunction-associated steatotic liver disease (MASLD) is the leading cause of chronic liver disease worldwide. This study investigates the role of serum miR-548ag in regulating lipid metabolism and its contribution to MASLD in obesity. We found that miR-548ag levels were significantly ele...

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Main Authors: Xiaolong Chu, Yanting Hou, Chaoling Peng, Wei Li, Maodi Liang, Jin Mei, Meiyu Qian, Juan Wang, Shibo Xu, Yidan Jiang, Xin Wen, Yao Chen, Fangyuan Yuan, Jianxin Xie, Cuizhe Wang, Jun Zhang
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Journal of Lipid Research
Subjects:
obesity
miR-548ag
DNMT3B
FASN
MASLD
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227525000781
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