Annonacin induces apoptosis and modulates programmed death-ligand 1 and interferon-gamma expression in triple-negative breast cancer: Integrated in silico and in vitro analysis

Background and Aim: Triple-negative breast cancer (TNBC) presents therapeutic challenges due to its aggressive nature and lack of targeted treatments. Programmed death-ligand 1 (PD-L1) and interferon-gamma (IFN-γ) are key immune modulators in tumor immune evasion. Annonacin, a natural acetogenin fro...

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Bibliographic Details
Main Authors: Retina Yunani, Sri Agus Sudjarwo, Mustofa Helmi Effendi, Rochmah Kurnijasanti, Nurul Hidayah
Format: Article
Language:English
Published: Veterinary World 2025-08-01
Series:Veterinary World
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Online Access:https://www.veterinaryworld.org/Vol.18/August-2025/8.pdf
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