Integrated network toxicology and bioinformatics reveal PFAS-driven prognostic biomarkers and molecular mechanisms in breast cancer: insights from transcriptome analysis and molecular docking

Integrated network toxicology and bioinformatics reveal PFAS-driven prognostic biomarkers and molecular mechanisms in breast cancer: insights from transcriptome analysis and molecular docking

Abstract Background Per- and polyfluoroalkyl substances (PFAS), pervasive environmental contaminants, are increasingly linked to breast cancer, yet their molecular mechanisms remain unclear. This study integrates network toxicology and bioinformatics to elucidate PFAS-associated pathways and prognos...

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Bibliographic Details
Main Authors: Yingqiang Fu, Yiyang Liu, Ziqi Sui
Format: Article
Language:English
Published: Springer 2025-07-01
Series:Discover Oncology
Subjects:
Per- and polyfluoroalkyl substances
Breast cancer
Network toxicology
Molecular docking
Tumor microenvironment
Bioinformatics
Online Access:https://doi.org/10.1007/s12672-025-03084-z
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https://doi.org/10.1007/s12672-025-03084-z

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