Resurrection of 2'-5'-oligoadenylate synthetase 1 (OAS1) from the ancestor of modern horseshoe bats blocks SARS-CoV-2 replication.

Resurrection of 2'-5'-oligoadenylate synthetase 1 (OAS1) from the ancestor of modern horseshoe bats blocks SARS-CoV-2 replication.

The prenylated form of the human 2'-5'-oligoadenylate synthetase 1 (OAS1) protein has been shown to potently inhibit the replication of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the virus responsible for the Coronavirus Disease 2019 (COVID-19) pandemic. However, the OAS...

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Bibliographic Details
Main Authors: Spyros Lytras, Arthur Wickenhagen, Elena Sugrue, Douglas G Stewart, Simon Swingler, Anna Sims, Hollie Jackson Ireland, Emma L Davies, Eliza M Ludlam, Zhuonan Li, Joseph Hughes, Sam J Wilson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-11-01
Series:PLoS Biology
Online Access:https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.3002398&type=printable
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https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.3002398&type=printable

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