New Nitrogen-, Oxygen-, and Sulfur-Containing Heterocyclic Compounds as Anti-Colon Cancer Agents: Synthesis, Multitargeted Evaluations, Molecular Docking Simulations and ADMET Predictions

New Nitrogen-, Oxygen-, and Sulfur-Containing Heterocyclic Compounds as Anti-Colon Cancer Agents: Synthesis, Multitargeted Evaluations, Molecular Docking Simulations and ADMET Predictions

<b>Background/Objectives:</b> Oxidative stress, the Warburg effect, and resistance to apoptosis are key hallmarks driving colorectal tumorigenesis. This study aimed to develop novel multi-target compounds capable of modulating these pathways. <b>Methods:</b> A library of 24 n...

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Main Authors: Nahed Nasser Eid El-Sayed, Najeh Krayem, Hamed Ahmed Derbala, Shimaa Kamal, Syde Nasir Abbas Bukhari, Mohamed K. El-Ashrey, Zainab M. Almarhoon, Seham Soliman Alterary, Abir Ben Bacha
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Pharmaceuticals
Subjects:
colorectal cancer
oxidative stress
Warburg effect
apoptosis
multitarget-directed ligands
heterocyclic compounds
Online Access:https://www.mdpi.com/1424-8247/18/6/801
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