PRPS activity tunes redox homeostasis in Myc-driven lymphoma

PRPS activity tunes redox homeostasis in Myc-driven lymphoma

Myc hyperactivation coordinately regulates numerous metabolic processes to drive lymphomagenesis. Here, we elucidate the temporal and functional relationships between the medley of pathways, factors, and mechanisms that cooperate to control redox homeostasis in Myc-overexpressing B cell lymphomas. W...

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Bibliographic Details
Main Authors: Austin C. MacMillan, Bibek Karki, Juechen Yang, Karmela R. Gertz, Samantha Zumwalde, Jay G. Patel, Maria F. Czyzyk-Krzeska, Jarek Meller, John T. Cunningham
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Redox Biology
Subjects:
Redox metabolism
Purine metabolism
Pentose phosphate pathway
Mitochondrial respiration
Enzymatic regulation
Oxidative/reductive stress
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231725001624
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