The zinc metalloprotein MigC impacts cell wall biogenesis through interactions with an essential Mur ligase in Acinetobacter baumannii.

The zinc metalloprotein MigC impacts cell wall biogenesis through interactions with an essential Mur ligase in Acinetobacter baumannii.

To colonize and survive in the host, bacterial pathogens like Acinetobacter baumannii must acquire zinc (Zn). To maintain Zn homeostasis, A. baumannii synthesizes proteins of the COG0523 family which are predicted to chaperone Zn to metalloproteins. Bioinformatic tools identified A. baumannii A1S_09...

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Main Authors: Jeanette M Critchlow, Joseph S Rocchio, Melanie C McKell, Courtney J Campbell, Juan P Barraza, Evan S Krystofiak, Erin R Green, Tae Akizuki, Walter J Chazin, Michael S VanNieuwenhze, Timothy L Stemmler, David P Giedroc, Eric P Skaar
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-06-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1013209
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https://doi.org/10.1371/journal.ppat.1013209

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