Azole fungicides: Potential endocrine disrupting effects and impact on placental steroidogenesis via inhibiting human and rat 3β-hydroxysteroid dehydrogenase

Azole fungicides: Potential endocrine disrupting effects and impact on placental steroidogenesis via inhibiting human and rat 3β-hydroxysteroid dehydrogenase

Azole fungicides disrupt pregnancy, but their effects on placental 3β-hydroxysteroid dehydrogenases (3β-HSDs) and structure-activity relationships (SARs) remain unclear. This study evaluated 9 azole fungicides for their inhibitory potency, mechanism, SAR, and docking interactions with human 3β-HSD1...

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Bibliographic Details
Main Authors: Jingyun Yan, Huan Chen, Zhongyao Ji, Yunbing Tang, Shaowei Wang, Jingyi Zheng, Huitao Li, Linxi Li, Ren-shan Ge, Yaoyao Dong
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Azole fungicide
Progesterone
Pregnenolone
3β-HSD1
Placenta
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651325008115
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http://www.sciencedirect.com/science/article/pii/S0147651325008115

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