Asfotase alfa restores PLP-dependent GABA, cystathionine, and amino acid metabolism in a mouse model of hypophosphatasia

Asfotase alfa restores PLP-dependent GABA, cystathionine, and amino acid metabolism in a mouse model of hypophosphatasia

This study assessed whether asfotase alfa treatment in Akp2-/- mice (a model of hypophosphatasia) reversibly normalizes GABA and cystathionine in brain tissue to concentrations in wild-type mice. To do this, metabolite concentrations were analyzed at postnatal days 10 and 48. The data showed that as...

Full description

Saved in:
Bibliographic Details
Main Authors: Kathryn N. Phoenix, Andre Marozsan, Susan Liu-Chen, Lizhong Zhang, Amit Mogha, Yan Wong, Catherine A. Brownstein, Raja Padidela
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Neuroscience Research
Subjects:
Hypophosphatasia
Alkaline phosphatase
Gamma-aminobutyric acid
Mice
Enzyme replacement therapy
Vitamin B6
Online Access:http://www.sciencedirect.com/science/article/pii/S0168010225001233
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

http://www.sciencedirect.com/science/article/pii/S0168010225001233

Similar Items