Local Administration of pCMV-VEGF165 Plasmid Encoding VEGF Stimulates Tissue Regeneration after Cold Injury in Rats

Local Administration of pCMV-VEGF165 Plasmid Encoding VEGF Stimulates Tissue Regeneration after Cold Injury in Rats

INTRODUCTION. Frostbite is a common cold injury that is associated with high rates of disability and requires long and difficult treatment. A vascular endothelial growth factor (VEGF)-encoding pCMV-VEGF165 plasmid-based gene therapy product designed for therapeutic angiogenesis may be a promising to...

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Main Authors: O. V. Shcheblykina, D. A. Kostina, V. V. Arkhipov, E. A. Patrakhanov, A. A. Dolzhikov, V. V. Gureev, N. I. Zhernakova, O. A. Osipova, M. V. Pokrovskii
Format: Article
Language:Russian
Published: Ministry of Health of the Russian Federation, Federal State Budgetary Institution «Scientific Centre for Expert Evaluation of Medicinal Products» 2025-06-01
Series:Безопасность и риск фармакотерапии
Subjects:
pcmv-vegf165 plasmid
vascular endothelial growth factor
frostbite
cold injury
regeneration
therapeutic angiogenesis
preclinical study
rats
Online Access:https://www.risksafety.ru/jour/article/view/482
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