Igf2 pathway dependency of the Trp53 developmental and tumour phenotypes

Igf2 pathway dependency of the Trp53 developmental and tumour phenotypes

Abstract Insulin‐like growth factor 2 (IGF2) and the transformation related protein 53 (Trp53) are potent regulators of cell growth and metabolism in development and cancer. In vitro evidence suggests several mechanistic pathway interactions. Here, we tested whether loss of function of p53 leads to...

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Bibliographic Details
Main Authors: Victoria L. Haley, David J. Barnes, Ionel Sandovici, Miguel Constancia, Christopher F. Graham, Francesco Pezzella, Claudia Bühnemann, Emma J. Carter, A. Bassim Hassan
Format: Article
Language:English
Published: Springer Nature 2012-06-01
Series:EMBO Molecular Medicine
Subjects:
embryogenesis
Igf2
p53
tumour predisposition
X‐linked
Online Access:https://doi.org/10.1002/emmm.201101105
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https://doi.org/10.1002/emmm.201101105

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