Serum Uromodulin as early marker for ischemic acute kidney injury and nephron loss: association with kidney tissue distribution pattern

Serum Uromodulin as early marker for ischemic acute kidney injury and nephron loss: association with kidney tissue distribution pattern

Abstract Background Uromodulin (UMOD) is expressed in kidneys and is mainly excreted in the urine, although a smaller amount is also released into the serum. Here, we investigated UMOD in acute kidney injury (AKI), with particular focus on the utility of serum UMOD as marker for nephron loss. Method...

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Bibliographic Details
Main Authors: Eva Vonbrunn, Nadja Ebert, Nada Cordasic, Kerstin Amann, Anke Büttner, Maike Büttner-Herold, Jürgen E. Scherberich, Christoph Daniel
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Journal of Translational Medicine
Subjects:
Uromodulin
Tamm-Horsfall protein
Ischemia/reperfusion
Acute kidney injury
Nephron loss
Online Access:https://doi.org/10.1186/s12967-025-06125-x
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https://doi.org/10.1186/s12967-025-06125-x

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