NGF-TrkA Axis Enhances PDGF-C-Mediated Angiogenesis in Osteosarcoma via miR-29b-3p Suppression: A Potential Therapeutic Strategy Using Larotrectinib

NGF-TrkA Axis Enhances PDGF-C-Mediated Angiogenesis in Osteosarcoma via miR-29b-3p Suppression: A Potential Therapeutic Strategy Using Larotrectinib

Angiogenesis plays a critical role in osteosarcoma (OS) growth and metastasis. While nerve growth factor (NGF) is implicated in cancer progression, its role in OS angiogenesis remains unclear. This study explored NGF’s effects on angiogenesis and the underlying molecular mechanisms. Analysis of GEO...

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Bibliographic Details
Main Authors: Sheng-Mou Hou, Ching-Yuan Cheng, Wei-Li Chen, En-Ming Chang, Chih-Yang Lin
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Life
Subjects:
osteosarcoma
NGF
larotrectinib
angiogenesis
miR-29b-3p
Online Access:https://www.mdpi.com/2075-1729/15/1/99
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