Tyro3 and Gas6 are associated with white matter and myelin integrity in multiple sclerosis

Tyro3 and Gas6 are associated with white matter and myelin integrity in multiple sclerosis

Abstract Background The Gas6/TAM (Tyro3, Axl, and Mer) receptor system has been implicated in demyelination and delayed remyelination in experimental animal models, but data in humans are scarce. We aimed to investigate the role of Gas6/TAM in neurodegenerative processes in multiple sclerosis (MS)....

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Main Authors: Igal Rosenstein, Lenka Novakova, Hlin Kvartsberg, Anna Nordin, Sofia Rasch, Elzbieta Rembeza, Sofia Sandgren, Clas Malmeström, Stefanie Fruhwürth, Markus Axelsson, Kaj Blennow, Henrik Zetterberg, Jan Lycke
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Journal of Neuroinflammation
Subjects:
Innate immunity
Demyelination
Remyelination
Quantitative MRI
Biomarkers
Online Access:https://doi.org/10.1186/s12974-024-03315-0
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https://doi.org/10.1186/s12974-024-03315-0

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