Goblet cell breakdown: transcriptomics reveals Acinetobacter baumannii early and robust inflammatory response in differentiated human bronchial epithelial cells

Goblet cell breakdown: transcriptomics reveals Acinetobacter baumannii early and robust inflammatory response in differentiated human bronchial epithelial cells

Abstract Background The airway epithelium represents the first line of defense of the lungs, functioning both as a physical barrier as well as an active immune modulator. However, in the last years, pneumonia caused by the opportunistic pathogen Acinetobacter baumannii have become difficult to treat...

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Bibliographic Details
Main Authors: Daniela Scribano, Claudia Tito, Astri D. Tagueha, Martina Pasqua, Luciana De Angelis, Francesco Fazi, Dolores Limongi, Marta De Angelis, Lucia Nencioni, Anna Teresa Palamara, Cecilia Ambrosi
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Biomedical Science
Subjects:
Air liquid interface epithelium
2D co-culture
Infection model
Acinetobacter baumannii
Host–pathogen interaction
Transcriptome
Online Access:https://doi.org/10.1186/s12929-025-01159-1
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https://doi.org/10.1186/s12929-025-01159-1

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