Unveiling the powerhouse: ASCL1-driven small cell lung cancer is characterized by higher numbers of mitochondria and enhanced oxidative phosphorylation

Unveiling the powerhouse: ASCL1-driven small cell lung cancer is characterized by higher numbers of mitochondria and enhanced oxidative phosphorylation

Abstract Background Small cell lung cancer (SCLC) is an aggressive malignancy with distinct molecular subtypes defined by transcription factors and inflammatory characteristics. This follow-up study aimed to validate the unique metabolic phenotype in achaete-scute homologue 1 (ASCL1)-driven SCLC cel...

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Main Authors: Anna Solta, Büsra Ernhofer, Kristiina Boettiger, Christian Lang, Zsolt Megyesfalvi, Theresa Mendrina, Dominik Kirchhofer, Gerald Timelthaler, Beata Szeitz, Melinda Rezeli, Clemens Aigner, Arvand Haschemi, Lukas W. Unger, Balazs Dome, Karin Schelch
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Cancer & Metabolism
Subjects:
Small cell lung cancer
Metabolism
Oxidative phosphorylation
Molecular subtypes
Online Access:https://doi.org/10.1186/s40170-025-00382-6
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https://doi.org/10.1186/s40170-025-00382-6

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