<i>Withania somnifera</i> Ameliorates Doxorubicin-Induced Nephrotoxicity and Potentiates Its Therapeutic Efficacy Targeting SIRT1/Nrf2, Oxidative Stress, Inflammation, and Apoptosis

<i>Withania somnifera</i> Ameliorates Doxorubicin-Induced Nephrotoxicity and Potentiates Its Therapeutic Efficacy Targeting SIRT1/Nrf2, Oxidative Stress, Inflammation, and Apoptosis

<b>Background</b>: Doxorubicin (DOX) is a very powerful chemotherapy drug. However, its severe toxicity and potential for resistance development limit its application. <i>Withania somnifera</i> L. Dunal (WIT) has therapeutic capacities, including anti-inflammatory, antioxidan...

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Bibliographic Details
Main Authors: Amany Mohammed Mohmmed Hegab, Soha Osama Hassanin, Reham Hassan Mekky, Samah Sulaiman Abuzahrah, Alaaeldin Ahmed Hamza, Iman M. Talaat, Amr Amin
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Pharmaceuticals
Subjects:
doxorubicin
<i>Withania somnifera</i>
nephrotoxicity
anti-inflammatory
therapeutic efficacy
oxidative stress
Online Access:https://www.mdpi.com/1424-8247/18/2/248
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