Repurposing Lesogaberan to Promote Human Islet Cell Survival and β-Cell Replication
The activation of β-cell’s A- and B-type gamma-aminobutyric acid receptors (GABAA-Rs and GABAB-Rs) can promote their survival and replication, and the activation of α-cell GABAA-Rs promotes their conversion into β-cells. However, GABA and the most clinically applicable GABA-R ligands may be suboptim...
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Main Authors: | , , , , |
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Format: | Article |
Language: | English |
Published: |
Wiley
2017-01-01
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Series: | Journal of Diabetes Research |
Online Access: | http://dx.doi.org/10.1155/2017/6403539 |
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