Repurposing Lesogaberan to Promote Human Islet Cell Survival and β-Cell Replication

The activation of β-cell’s A- and B-type gamma-aminobutyric acid receptors (GABAA-Rs and GABAB-Rs) can promote their survival and replication, and the activation of α-cell GABAA-Rs promotes their conversion into β-cells. However, GABA and the most clinically applicable GABA-R ligands may be suboptim...

Full description

Saved in:
Bibliographic Details
Main Authors: Jide Tian, Hoa Dang, Angela Hu, Willem Xu, Daniel L. Kaufman
Format: Article
Language:English
Published: Wiley 2017-01-01
Series:Journal of Diabetes Research
Online Access:http://dx.doi.org/10.1155/2017/6403539
Tags: Add Tag
No Tags, Be the first to tag this record!