The surface protein Gbp of Fusobacterium nucleatum inhibits osteogenic differentiation by inactivating the Wnt/β-catenin pathway via binding to Annexin A2

The surface protein Gbp of Fusobacterium nucleatum inhibits osteogenic differentiation by inactivating the Wnt/β-catenin pathway via binding to Annexin A2

Abstract Background Periodontitis is a chronic inflammatory disease that significantly impacts periodontal bone regeneration, yet the distinct biological features of osteoblasts in this condition remain poorly understood. This study aims to elucidate the cellular and molecular mechanisms underlying...

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Main Authors: Rui Dong, Meihui Li, Xiu Feng Gu, Haiting Gao, Ziyi Wei, Houbao Qi, Jun Zhang, Qiang Feng
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Journal of Translational Medicine
Subjects:
Fusobacterium nucleatum
Osteogenic differentiation
Gbp
ANXA2
Online Access:https://doi.org/10.1186/s12967-025-06569-1
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https://doi.org/10.1186/s12967-025-06569-1

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