Symptom Network and Subgroup Analysis in Patients with Exacerbation of Chronic Obstructive Pulmonary Disease: A Cross-Sectional Study
Chunchun Yu,1 Mengying Xu,1 Xinyue Pang,2 Yuting Zhang,3 Xinmei Cao,2 Yixin Xu,1 Shuai Huang,1 Hongjun Zhao,4 Chengshui Chen1,3,4 1Key Laboratory of Interventional Pulmonology of Zhejiang Province, Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical U...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2025-01-01
|
| Series: | International Journal of COPD |
| Subjects: | |
| Online Access: | https://www.dovepress.com/symptom-network-and-subgroup-analysis-in-patients-with-exacerbation-of-peer-reviewed-fulltext-article-COPD |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832590371140403200 |
|---|---|
| author | Yu C Xu M Pang X Zhang Y Cao X Xu Y Huang S Zhao H Chen C |
| author_facet | Yu C Xu M Pang X Zhang Y Cao X Xu Y Huang S Zhao H Chen C |
| author_sort | Yu C |
| collection | DOAJ |
| description | Chunchun Yu,1 Mengying Xu,1 Xinyue Pang,2 Yuting Zhang,3 Xinmei Cao,2 Yixin Xu,1 Shuai Huang,1 Hongjun Zhao,4 Chengshui Chen1,3,4 1Key Laboratory of Interventional Pulmonology of Zhejiang Province, Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, People’s Republic of China; 2Zhejiang Province, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, People’s Republic of China; 3Cixi Biomedical Research Institute, Wenzhou Medical University, Wenzhou, Zhejiang, 315302, People’s Republic of China; 4Zhejiang Province Engineering Research Center for Endoscope Instruments and Technology Development, Department of Pulmonary and Critical Care Medicine, Quzhou People’s Hospital, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou, 324000, People’s Republic of ChinaCorrespondence: Hongjun Zhao; Chengshui Chen, Zhejiang Province Engineering Research Center for Endoscope Instruments and Technology Development, Department of Pulmonary and Critical Care Medicine, Quzhou People’s Hospital, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou, 324000, People’s Republic of China, Email zhaohongjun@wmu.edu.cn; chenchengshui@wmu.edu.cnPurpose: This study aims to construct a contemporaneous symptom network of inpatients with Exacerbation of Chronic Obstructive Pulmonary Disease (ECOPD) based on the symptom cluster, identify core and bridge symptoms, and patient subgroups with different symptom clusters based on individual differences in the intensity of patient symptom experiences.Patients and Methods: This study used convenience sampling to collect demographic, symptom, auxiliary examination, and prognosis information of 208 inpatients with ECOPD from April 2022 to October 2023. The data underwent exploratory factor analysis (EFA), symptom network analysis, latent class analysis (LCA), Spearman correlation analysis, Wilcoxon signed-rank test, single-factor regression and multiple-factor stepwise regression.Results: In hospitalized patients with ECOPD, symptom network analysis revealed that loss of appetite was the core symptom, while chest distress was the bridge symptom. Through LCA analysis, two symptom subgroups were identified: a high-symptom group (53.8%) and a low-symptom group (46.2%). This suggests that there is significant heterogeneity in symptom experience among ECOPD individuals. Patients in the high-symptom group had a higher probability of experiencing symptom clusters related to nutrition-sleep.Conclusion: The combination of symptom network analysis and LCA comprehensively captures the symptom/symptom cluster characteristics and accounts for the heterogeneity of ECOPD patients from both individual and group perspectives. This study identifies core symptoms, bridge symptoms, and symptom subgroups, offering valuable insights for precision symptom management in ECOPD.Keywords: chronic obstructive pulmonary disease, COPD, exacerbation, precision care, network analysis, latent class analysis |
| format | Article |
| id | doaj-art-036ccd6ae3a94464bf24af5d210a68a1 |
| institution | Kabale University |
| issn | 1178-2005 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of COPD |
| spelling | doaj-art-036ccd6ae3a94464bf24af5d210a68a12025-01-23T18:50:33ZengDove Medical PressInternational Journal of COPD1178-20052025-01-01Volume 2018119299541Symptom Network and Subgroup Analysis in Patients with Exacerbation of Chronic Obstructive Pulmonary Disease: A Cross-Sectional StudyYu CXu MPang XZhang YCao XXu YHuang SZhao HChen CChunchun Yu,1 Mengying Xu,1 Xinyue Pang,2 Yuting Zhang,3 Xinmei Cao,2 Yixin Xu,1 Shuai Huang,1 Hongjun Zhao,4 Chengshui Chen1,3,4 1Key Laboratory of Interventional Pulmonology of Zhejiang Province, Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, People’s Republic of China; 2Zhejiang Province, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, People’s Republic of China; 3Cixi Biomedical Research Institute, Wenzhou Medical University, Wenzhou, Zhejiang, 315302, People’s Republic of China; 4Zhejiang Province Engineering Research Center for Endoscope Instruments and Technology Development, Department of Pulmonary and Critical Care Medicine, Quzhou People’s Hospital, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou, 324000, People’s Republic of ChinaCorrespondence: Hongjun Zhao; Chengshui Chen, Zhejiang Province Engineering Research Center for Endoscope Instruments and Technology Development, Department of Pulmonary and Critical Care Medicine, Quzhou People’s Hospital, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou, 324000, People’s Republic of China, Email zhaohongjun@wmu.edu.cn; chenchengshui@wmu.edu.cnPurpose: This study aims to construct a contemporaneous symptom network of inpatients with Exacerbation of Chronic Obstructive Pulmonary Disease (ECOPD) based on the symptom cluster, identify core and bridge symptoms, and patient subgroups with different symptom clusters based on individual differences in the intensity of patient symptom experiences.Patients and Methods: This study used convenience sampling to collect demographic, symptom, auxiliary examination, and prognosis information of 208 inpatients with ECOPD from April 2022 to October 2023. The data underwent exploratory factor analysis (EFA), symptom network analysis, latent class analysis (LCA), Spearman correlation analysis, Wilcoxon signed-rank test, single-factor regression and multiple-factor stepwise regression.Results: In hospitalized patients with ECOPD, symptom network analysis revealed that loss of appetite was the core symptom, while chest distress was the bridge symptom. Through LCA analysis, two symptom subgroups were identified: a high-symptom group (53.8%) and a low-symptom group (46.2%). This suggests that there is significant heterogeneity in symptom experience among ECOPD individuals. Patients in the high-symptom group had a higher probability of experiencing symptom clusters related to nutrition-sleep.Conclusion: The combination of symptom network analysis and LCA comprehensively captures the symptom/symptom cluster characteristics and accounts for the heterogeneity of ECOPD patients from both individual and group perspectives. This study identifies core symptoms, bridge symptoms, and symptom subgroups, offering valuable insights for precision symptom management in ECOPD.Keywords: chronic obstructive pulmonary disease, COPD, exacerbation, precision care, network analysis, latent class analysishttps://www.dovepress.com/symptom-network-and-subgroup-analysis-in-patients-with-exacerbation-of-peer-reviewed-fulltext-article-COPDchronic obstructive pulmonary disease (copd)exacerbationprecision carenetwork analysislatent class analysis. |
| spellingShingle | Yu C Xu M Pang X Zhang Y Cao X Xu Y Huang S Zhao H Chen C Symptom Network and Subgroup Analysis in Patients with Exacerbation of Chronic Obstructive Pulmonary Disease: A Cross-Sectional Study International Journal of COPD chronic obstructive pulmonary disease (copd) exacerbation precision care network analysis latent class analysis. |
| title | Symptom Network and Subgroup Analysis in Patients with Exacerbation of Chronic Obstructive Pulmonary Disease: A Cross-Sectional Study |
| title_full | Symptom Network and Subgroup Analysis in Patients with Exacerbation of Chronic Obstructive Pulmonary Disease: A Cross-Sectional Study |
| title_fullStr | Symptom Network and Subgroup Analysis in Patients with Exacerbation of Chronic Obstructive Pulmonary Disease: A Cross-Sectional Study |
| title_full_unstemmed | Symptom Network and Subgroup Analysis in Patients with Exacerbation of Chronic Obstructive Pulmonary Disease: A Cross-Sectional Study |
| title_short | Symptom Network and Subgroup Analysis in Patients with Exacerbation of Chronic Obstructive Pulmonary Disease: A Cross-Sectional Study |
| title_sort | symptom network and subgroup analysis in patients with exacerbation of chronic obstructive pulmonary disease a cross sectional study |
| topic | chronic obstructive pulmonary disease (copd) exacerbation precision care network analysis latent class analysis. |
| url | https://www.dovepress.com/symptom-network-and-subgroup-analysis-in-patients-with-exacerbation-of-peer-reviewed-fulltext-article-COPD |
| work_keys_str_mv | AT yuc symptomnetworkandsubgroupanalysisinpatientswithexacerbationofchronicobstructivepulmonarydiseaseacrosssectionalstudy AT xum symptomnetworkandsubgroupanalysisinpatientswithexacerbationofchronicobstructivepulmonarydiseaseacrosssectionalstudy AT pangx symptomnetworkandsubgroupanalysisinpatientswithexacerbationofchronicobstructivepulmonarydiseaseacrosssectionalstudy AT zhangy symptomnetworkandsubgroupanalysisinpatientswithexacerbationofchronicobstructivepulmonarydiseaseacrosssectionalstudy AT caox symptomnetworkandsubgroupanalysisinpatientswithexacerbationofchronicobstructivepulmonarydiseaseacrosssectionalstudy AT xuy symptomnetworkandsubgroupanalysisinpatientswithexacerbationofchronicobstructivepulmonarydiseaseacrosssectionalstudy AT huangs symptomnetworkandsubgroupanalysisinpatientswithexacerbationofchronicobstructivepulmonarydiseaseacrosssectionalstudy AT zhaoh symptomnetworkandsubgroupanalysisinpatientswithexacerbationofchronicobstructivepulmonarydiseaseacrosssectionalstudy AT chenc symptomnetworkandsubgroupanalysisinpatientswithexacerbationofchronicobstructivepulmonarydiseaseacrosssectionalstudy |