Analysis of the association between CIMP and BRAF in colorectal cancer by DNA methylation profiling.

Analysis of the association between CIMP and BRAF in colorectal cancer by DNA methylation profiling.

A CpG island methylator phenotype (CIMP) is displayed by a distinct subset of colorectal cancers with a high frequency of DNA hypermethylation in a specific group of CpG islands. Recent studies have shown that an activating mutation of BRAF (BRAF(V600E)) is tightly associated with CIMP, raising the...

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Main Authors: Toshinori Hinoue, Daniel J Weisenberger, Fei Pan, Mihaela Campan, Myungjin Kim, Joanne Young, Vicki L Whitehall, Barbara A Leggett, Peter W Laird
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-12-01
Series:PLoS ONE
Online Access:https://europepmc.org/articles/pmc2791229?pdf=render
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https://europepmc.org/articles/pmc2791229?pdf=render

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