Multiple Hits on Cerebral Folate, Tetrahydrobiopterin and Dopamine Metabolism in the Pathophysiology of Parkinson’s Disorder: A Limited Study of Post-Mortem Human Brain Tissues

Multiple Hits on Cerebral Folate, Tetrahydrobiopterin and Dopamine Metabolism in the Pathophysiology of Parkinson’s Disorder: A Limited Study of Post-Mortem Human Brain Tissues

<b>Background</b>: Parkinson’s disorder (PD) affects around 1:500 individuals and is associated with enlarged ventricles and symptoms of normal pressure hydrocephalus (NPH). These features suggest disrupted cerebrospinal fluid (CSF) dynamics and folate metabolism. With L-DOPA treatment s...

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Bibliographic Details
Main Authors: Dhruti Balakrishna Doddaballapur, Derren J. Heyes, Jaleel A. Miyan
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Metabolites
Subjects:
neurodegeneration
cerebrospinal fluid metabolism
oxidative stress
enzyme dysfunction
choroid plexus
biogenic amine synthesis
Online Access:https://www.mdpi.com/2218-1989/15/5/307
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