Plasma concentrations of extracellular vesicles correlate with inflammatory markers in patients with aortic stenosis undergoing surgical aortic valve replacement
INTRODUCTION: In severe aortic stenosis (AS), turbulent flow through the calcified valve leaflets creates shear stress and causes abnormal activation and destruction of blood elements. Activated and damaged blood cells release extracellular vesicles (EVs), which are novel biomarkers of systemic infl...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Via Medica
2025-07-01
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| Series: | Folia Cardiologica |
| Subjects: | |
| Online Access: | https://journals.viamedica.pl/folia_cardiologica/article/view/102238 |
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| Summary: | INTRODUCTION: In severe aortic stenosis (AS), turbulent flow through the calcified valve leaflets creates shear stress and causes abnormal activation and destruction of blood elements. Activated and damaged blood cells release extracellular vesicles (EVs), which are novel biomarkers of systemic inflammation and aortic valve calcification. The effect of surgical aortic valve replacement (SAVR) on EVs has not been elucidated. OBJECTIVE: We aimed to investigate the effect of SAVR on plasma concentrations of EVs and inflammatory markers, and we evaluated the correlation between them. MATERIAL AND METHODS: The study group comprised 10 patients [median (IQR) age 69 (64–74) years] referred for SAVR due to severe AS. Blood samples for hematological indices, inflammatory markers, and EVs were collected before SAVR and at the 1st and 3rd postoperative day. RESULTS: Concentrations of EVs from leukocytes (CD45+) decreased on postoperative day 1 and returned to baseline on postoperative day 3 (p = 0.027). There was a negative correlation between EVs from erythrocytes (CD235+) and inflammatory indices (neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, and systemic inflammatory index) before SAVR, with no other significant correlations between EVs and inflammatory indices. CONCLUSIONS: SAVR leads to a transient decrease in pro-inflammatory leukocyte-derived EVs, with their levels returning to baseline by postoperative day 3, suggesting an anti-inflammatory effect of this procedure. A negative correlation between erythrocyte-derived EVs (CD235+) and preoperative inflammation before SAVR indicates a potential cardioprotective role of these EVs in patients with AS. Our preliminary findings warrant validation in a larger study. |
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| ISSN: | 2353-7752 2353-7760 |